|
KMID : 0363619960170010132
|
|
Journal of Korean Oriental Medicine
1996 Volume.17 No. 1 p.132 ~ p.145
|
|
|
Antimetastatic effect of several crude drugs with antitumor activity on B16-Fo and A549 cells( II ))
|
|
Kim Sung-Hoon
Ryu Shi-Yong
|
|
|
Abstract
|
|
|
|
Ethyl ether fractions of Ferula Resina(EFR) and Lithospermi Radix(ELR) and hexane fraction of Salviae miltiorrhizae Radix(HSR) exerted an inhibitory effect on cell adhesion of A549 to extracelluar matrix most effectively in vitro cell adhesion assay. Thus, with above fractions for the evaluation of antitumor activity, T／C% was monitored in ICR bearing S-180 and for antimetastatic effect, pulmonary colonization assay, weight of organs, changes of WBC and platelet were studied. In pulmonary colonization assay incidence rate to control was 73 % 42 %, 14 % in ELR, HSR and EFR-treated groups repsectively. Gain of lung weight was significantly inhibited in all groups while spleen weight was significantly reduced only in SMR group, but no changes in kidney and liver as compared with control. Number of platelet was significantly increased in all groups to normal range as compared with thrombocytopenic contol. WBC was significantly reduced only in LR group. These results suggest that ethyl ether fraction of Ferula Resina has more effective antimetastatic activity.
|
|
|
KEYWORD
|
|
|
Antimetastatic effect, Ferula Resina, Lithospermi Radix, Saliviae militiorrhizae Radix
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|